About this course

Migraine headache is the second most disabling neurological condition worldwide. Studies have shown that calcitonin gene-related peptide (CGRP) plays a major role in migraine pain transmission in the trigeminovascular system, hence, it has been the target of recent therapeutic interventions. CGRP antagonists are shown to be effective in addressing both the acute and preventive therapeutic goals of migraine headaches.

This e-learning module reviews the causes of migraine, its clinical manifestations, major classifications, and discusses the role of CGRP antagonists as novel treatment options.

Learning outcomes

• Review the classification and clinical manifestations of migraine headache.
• Understand the role of CGRP in the pathophysiology of migraine headache.
• Discuss the emerging therapeutic interventions for migraine headaches, with emphasis on the role of CGRP antagonists.

Topics covered

• Introduction
• Global burden of disease of migraine headaches
• Clinical manifestations and classifications of migraine headaches
• Pathophysiology: Role of CGRP in the pathophysiology of migraine headaches
• Emerging therapeutic interventions for migraine headaches
• Acute treatment
• Preventive treatment
• Gaps in the current treatment approach to migraine headaches
• Clinical trials on CGRP antagonists and recent updates